Biogenic amine metabolites in human CSF after hypoxia due to cardiac arrest
article
The concentrations of 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindole-3-acetic acid (5-HIAA) and homovanillic acid (HVA) were determined in CSF of patients with hypoxia due to circulatory arrest. Patients were divided into neurologically disabled and recovered according to the Glasgow Coma Scale. CSF was collected 4, 28, 76 and 172 h after commencement of resuscitation and once from control patients subjected to spinal anaesthesia. The initial concentrations of MHPG, 5-HIAA and HVA were significantly higher in a subgroup of neurologically disabled patients who died within 76 h. In recovered patients the concentration of MHPG declined with time to the value of the control group, whereas it increased in neurologically disabled patients. In the latter group the concentration of 5-HIAA also showed an increase with time, whereas in recovered patients it declined after an initial rise. It is concluded that high concentrations of MHPG, 5-HIAA and HVA in CSF may be prognostic for hypoxic brain injury after cardiac arrest.
Chemicals/CAS: 4 hydroxy 3 methoxyphenylethylene glycol, 534-82-7; 5 hydroxyindoleacetic acid, 1321-73-9, 54-16-0; homovanillic acid, 306-08-1; Biogenic Amines; Glycols; Homovanillic Acid, 306-08-1; Hydroxyindoleacetic Acid, 54-16-0; Methoxyhydroxyphenylglycol, 534-82-7
Chemicals/CAS: 4 hydroxy 3 methoxyphenylethylene glycol, 534-82-7; 5 hydroxyindoleacetic acid, 1321-73-9, 54-16-0; homovanillic acid, 306-08-1; Biogenic Amines; Glycols; Homovanillic Acid, 306-08-1; Hydroxyindoleacetic Acid, 54-16-0; Methoxyhydroxyphenylglycol, 534-82-7
Topics
4 hydroxy 3 methoxyphenylethylene glycol5 hydroxyindoleacetic acidhomovanillic acidadultagedcerebrospinal fluidclinical articlefatalityfemaleheart arresthumanhypoxiamalepriority journalAgedAged, 80 and overAnoxiaBiogenic AminesFemaleGlycolsHeart ArrestHomovanillic AcidHumanHydroxyindoleacetic AcidMaleMethoxyhydroxyphenylglycolMiddle AgeSupport, Non-U.S. Gov't
TNO Identifier
230834
ISSN
00016314
Source
Acta Neurologica Scandinavica, 80(1), pp. 6-11.
Pages
6-11
Files
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