Kuppfer cells and the acute phase response: The effect of aging
article
Aging is associated with a significant increase in the susceptibility to scepsis and endotoxin induced shock in both man and experimental animals. In this study, some metabolic, haemodynamic and other pathophysiological factors possibly involved in the increased mortality of aged rats after endotoxin administration were investigated. The results indicate that older rats display an overall decrease in the capacity to maintain homeostasis after endotoxin challenge, which is expressed by severe disregulation of body temperature (hypothermia), glucose metabolism (hypoglycemia), tissue perfusion (fibrinolytic and anti-fibrinolytic factors) and severe tissue damage. Although a slight decrease in the clearance of endotoxin from the circulation was noted in old rats, alterations in the secondary response, evoked by stimulated macrophages and other cells appear to be more important in the age-related increase in susceptibility.
Chemicals/CAS: Endotoxins; Prostaglandins
Chemicals/CAS: Endotoxins; Prostaglandins
Topics
endotoxinprostaglandinageagedaginganimal experimentcontrolled studyfemalehemodynamicshomeostasishypoglycemiahypothermiamacrophagemetabolismnonhumanpathophysiologypriority journalprovocation testratsepsistissue perfusionultrastructureacute phase responseanimalarticlebiosynthesisbloodcytologydrug effectendocytosishumaninflammationKupffer cellmetabolic clearance ratepathologyphysiologyrat strainAcute-Phase ReactionAgingAnimalEndocytosisEndotoxinsFemaleHomeostasisHumanInflammationKupffer CellsMetabolic Clearance RateProstaglandinsRatsRats, Inbred BN
TNO Identifier
230787
ISSN
08820139
Source
Immunological Investigations, 18(1-4), pp. 339-350.
Pages
339-350
Files
To receive the publication files, please send an e-mail request to TNO Repository.