Induction of lipid droplets in fibroblasts of the hamster lung by a diet high in vitamin A

article
Spit, B.J.
To investigate the effect of vitamin A on the occurrence of lipid droplets in alveolar fibroblasts, light and electron microscopic studies were carried out on the lungs of Syrian golden hamsters fed on diets with a low, normal, or high vitamin A content for a period of 17 weeks. The feeding of the high vitamin A diet resulted in a considerable increase in size and number of lipid droplets in alveolar fibroblasts. These droplets also occurred in fibroblasts of the visceral pleura, and in fibroblasts of connective tissue around bronchioli and larger blood vessels. Most of the lipid-laden fibroblasts could be recognized as myofibroblasts. The significance of the droplets for the deposition of interstitial materials or for the synthesis of prostaglandins is discussed.
Chemicals/CAS: retinol, 68-26-8, 82445-97-4; Lipids; Vitamin A, 11103-57-4
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fat dropletretinolanimal experimentbronchioledietdrug overdosefibroblasthistologyintoxicationlung alveoluslung toxicitynonhumanpleurarespiratory systemAnimalBody WeightCytoskeletonFibroblastsHamstersInclusion BodiesLipidsMaleMesocricetusPulmonary AlveoliVitamin A
TNO Identifier
229472
Repository link
https://resolver.tno.nl/uuid:0a46f3e1-2895-44ce-bef2-5f517ae2cd8f
ISSN
01902148
Source
Experimental Lung Research, 4(4), pp. 247-257.
Pages
247-257
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