Further evidence for the effect of pinacolyl dimethylphosphinate on soman storage in muscle tissue

article


Dongen, C.J. van

Helden, H.P.M. van

Wolthuis, O.L.
Diaphragms isolated from rats 60 or 120 min after the intravenous injection of 6 x LD50 soman were incubated with electric eel acetylcholinesterase. As calculated from the enzyme inhibition, detectable amounts of P(-)-soman (1,2-dimethylpropyl methylphosphonofluoridate) were released from the diaphragm into the medium even 120 min post-injection. This release was reduced by additional pretreatment of the rats with pinacolyl dimethylphosphinate, providing further evidence that this compound prevents the storage of soman in diaphragm tissue.
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Adverse drug reactionAnimal cellBlood and hemopoietic systemDiaphragmDimethylphosphinic acid pinacolyl esterDrug efficacyDrug retentionIntravenous drug administrationMethodologyMuscleAnimalCholinesterase InhibitorsMaleMuscle, SmoothRats, Inbred StrainsAcetylcholinesterase, 9000-81-1Soman, 96-64-0Cholinesterase inhibitorsPinacolyl dimethylphosphinate, 92411-69-3
TNO Identifier
230113
Repository link
https://resolver.tno.nl/uuid:64d8f602-3bef-4165-af08-0393f756f7a3
ISSN
0014-2999
Source
European Journal of Pharmacology, 127(1-2), pp. 135-138.
Pages
135-138
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