Hippuran transit times in the kidney: A new approach
article
Deconvolution of a renogram curve with the Hippuran concentration of the plasma is a procedure for finding the impulse response function H(t), which represents the probability that a Hippuran molecule, entering the kidney at zero time, is still present in the organ at a time t. The initial value of this function is one by definition. It may remain constant for a while but it should never increase and ultimately it should approach zero. Fleming and Goddard (1973) introduced a deconvolution technique for the renogram in which the Laplace transformation of the function I(t), the Hippuran concentration in the plasma, plays a role. This means that a mathematical expression must be found which is not too complicated for the required operations and is nevertheless a sufficiently close approximation of I(t). A three-exponential function I(t) is proposed. Much effort is saved by first computing the integral G(t) of the impulse response function. It is easily differentiated graphically and moreover it provides a simple means for finding the average transit time.
Chemicals/CAS: iodohippurate sodium i 131, 881-17-4; iodohippuric acid, 133-17-5; Iodohippuric Acid, 147-58-0
Chemicals/CAS: iodohippurate sodium i 131, 881-17-4; iodohippuric acid, 133-17-5; Iodohippuric Acid, 147-58-0
Topics
TNO Identifier
228438
ISSN
00319155
Source
Physics in Medicine and Biology, 23(2), pp. 291-301.
Pages
291-301
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