Fibrinolytic activity of the gastric mucosa in Menetrier's disease

article

Wijngaards, G.

Jespersen, J.
Biopsies of the gastric mucosa were collected from two patients with Menetrier's disease before, during, and after treatment with cimetidine and studied for fibrinolytic activity. The fibrinolytic activity in the homogenates or in the potassium thiocyanate soluble fractions increased markedly during the treatment. Immunological characterization of the activity indicated that its major component was an endothelium-derived type of plasminogen activator, and that the increase in activity was caused solely by an increase in the concentration of this component. This suggests an increase in the vascularity of the mucosal layers during treatment thus reflecting a repair process.
Chemicals/CAS: cimetidine, 51481-61-9, 70059-30-2; plasminogen activator, 9039-53-6; Cimetidine, 51481-61-9; Plasminogen Activators, EC 3.4.21.-
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cimetidineplasminogen activatorradioisotopealbumin cr 51case reportcytologydiagnosishistologymenetrier diseaseprotein losing gastroenteropathystomachstomach biopsyCase ReportCimetidineFibrinolysisGastric MucosaGastritisGastritis, HypertrophicHumanMaleMiddle AgePlasminogen ActivatorsSupport, Non-U.S. Gov't
TNO Identifier
229387
Repository link
https://resolver.tno.nl/uuid:ef23b5bb-c636-494b-9578-d3b2a9075d53
ISSN
00142972
Source
European Journal of Clinical Investigation, 13(4), pp. 347-350.
Pages
347-350
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