High density lipoprotein cholesterol and apolipoprotein A-I levels in 32 to 33-year-old women on steroid contraceptives - differences between two frequently used low-estrogen pills

article




Havekes, L.

Gent, C.M. van

Stegerhoek, C.I.

Arntzenius, A.C.

Hessel, L.W.
High density lipoprotein cholesterol and apolipoprotein A-I levels were measured in about one thousand 32 to 33-year-old women taking part in a cardiovascular screening programme. After corrections for differences in smoking habits and use of alcoholic drinks women on various types of steroid contraceptives had widely different levels of high density lipoprotein cholesterol and apolipoprotein A-I. Lowest levels were found in users of lynestrenol-containing minipills (progestagen-only pills) and highest levels in lynestrenol-containing low-estrogen pills. Of the two commonly used low-estrogen pills ('sub-50 pills') one type (containing lynestrenol) was associated with elevated and the other (containing levonorgestrel) with depressed levels of high density lipoprotein cholesterol and apolipoprotein A-I as compared with the reference group of non-users of oral contraceptives.
Chemicals/CAS: cholesterol, 57-88-5; lynestrenol, 52-76-6; norgestrel, 6533-00-2; Apolipoprotein A-I; Apolipoproteins; Cholesterol, 57-88-5; Contraceptives, Oral; Delayed-Action Preparations; Ethinyl Estradiol, 57-63-6; Lipoproteins, HDL Cholesterol; Lipoproteins, HDL; Lynestrenol, 52-76-6; Medroxyprogesterone 17-Acetate, 71-58-9; Medroxyprogesterone, 520-85-4; Mestranol, 72-33-3; Norethindrone, 68-22-4
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AdultAlcohol DrinkingApolipoprotein A-IApolipoproteinsCholesterolComparative StudyContraceptives, OralDelayed-Action PreparationsEthinyl EstradiolFemaleHumanLipoproteins, HDLLipoproteins, HDL CholesterolLynestrenolMedroxyprogesteroneMedroxyprogesterone 17-AcetateMestranolNorethindroneSmoking
TNO Identifier
229048
Repository link
https://resolver.tno.nl/uuid:e5ffcdef-5044-4a30-94bf-724b61a3243a
ISSN
00098981
Source
Clinica Chimica Acta, 116(2), pp. 223-229.
Pages
223-229
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