The effects of 4-aminopyridine on cognitive function in patients with multiple sclerose : a pilot study

article





Smits, R.C.F.

Emmen, H.H.

Bertelmans, F.W.

Kulig, B.M.

Loenen, A.C. van

Polman, C.H.
4-Aminopyridine (4-AP) has a favorable effect on the disability of certain patients with MS. We investigated the effect of 4-AP on neuropsychological performance in 20 MS patients using a randomized, double-blind, placebo- controlled, crossover design. Although there was a trend for improved performance with 4-AP for two of the tests, we could not demonstrate significant effects of 4-AP on cognitive function.
Chemicals/CAS: 4-Aminopyridine, 504-24-5; Placebos
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4 AminopyridineClinical articleClinical trialCognitionControlled clinical trialControlled studyCrossover procedureDouble blind procedureHearing testMultiple sclerosisNeuropsychological testOral drug administrationRandomized controlled trialTask performanceVerbal memoryVisual memory4-AminopyridineAdultAgedCognition DisordersDouble-Blind MethodFemaleHumansMaleMiddle AgedMultiple SclerosisNeuropsychological TestsPilot ProjectsPlacebos
TNO Identifier
36538
Repository link
https://resolver.tno.nl/uuid:4b2644c2-694c-459d-95af-ce9eb032bfbc
Source
Neurology, 44, pp. 1701-1705.
Pages
1701-1705
Files
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