Age-related changes in CD4+ T-cell subsets associated with prolonged skin graft survival in aging rats

article




Tielen, F.J.

Vliet, A.C.M. van

Geus, B. de

Nagelkerken, L.

Rozing, J.
AGING is associated with major changes in the cellular immune system.1,2 One of the most striking differences between T cells obtained from young and old individuals is their ability to produce IL-2 upon stimulation. Whereas CD4’ T cells from young donors can produce high amounts of IL-2 after appropriate stimulation in vitro, such cells from older individuals are relatively deficient in this respect. Chemicals/CAS: interleukin 2, 85898-30-2
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cd4 antigeninterleukin 2interleukin 4alloimmunityanimal cellanimal experimentanimal tissuecell isolationcell stimulationconference papergraft rejectionmemory cellnonhumanphenotypesenescenceskin graftskin transplantationt lymphocyte subpopulationAgingAnimalCD4-Positive T-LymphocytesFlow CytometryGraft SurvivalMaleRatsRats, Inbred BNRats, Inbred F344Skin TransplantationSupport, Non-U.S. Gov'tT-Lymphocyte SubsetsTime FactorsTransplantation, Homologous
TNO Identifier
232161
Repository link
https://resolver.tno.nl/uuid:4a5bd321-ab98-4d2b-aba4-7133eb2da560
ISSN
00411345
Source
Transplantation Proceedings, 25(5), pp. 2872-2874.
Pages
2872-2874
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