Interferon-β in multiple sclerosis: Altering the balance of interleukin-12 and interleukin-10?
article
Interferon-β is a remarkably pleiotropic molecule. Antiviral, pro and antiproliferative, pro- and antiapoptotic, and complex immunoregulatory activities have all been described. The precise mechanism(s) that underlie the beneficial effects of interferon-β in multiple sclerosis remain poorly understood; this has hindered progress in the search for more effective therapies. An increasing body of literature supports the hypothesis that interferon-β-mediated changes in the production and activities of the immunoregulatory cytokines interleukin-12 and interleukin-10 are important to the therapeutic benefits of interferon-β in multiple sclerosis. These data are reviewed here. © 2001 Lippincott Williams & Wilkins. Chemicals/CAS: Interferon-beta, 77238-31-4; Interleukin-10, 130068-27-8; Interleukin-12, 187348-17-0
Topics
TNO Identifier
236106
ISSN
13507540
Source
Current Opinion in Neurology, 14(3), pp. 361-368.
Pages
361-368
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