Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells
article
Human IL-1, recombinant murine IL-1 and E. coli LPS were found to be potent inducers of plasminogen activator (PA)-inhibitor activity, both in vivo, in rats, as well as in cultured human endothelial cells. In vivo, LPS rapidly and dose-dependently (0.01-1,000 ??g/kg) increased plasma PA-inhibitor activity. Infusion of IL-1 into rats resulted in a small but significant increase in PA-inhibitor activity in rat plasma. Likewise, in cultured human umbilical vein endothelial cells, LPS and IL-1 induced increased synthesis of PA-inhibitor. We suggest that the induced rat plasma inhibitor might be of endothelial origin.
Chemicals/CAS: cycloheximide, 642-81-9, 66-81-9; dactinomycin, 1402-38-6, 1402-58-0, 50-76-0; fibrinogen, 9001-32-5; interleukin 2, 85898-30-2; plasminogen activator inhibitor, 105844-41-5; plasminogen activator, 9039-53-6; plasminogen, 9001-91-6; Interleukin-1; Lipopolysaccharides; Recombinant Proteins; Tissue Plasminogen Activator, EC 3.4.21.68
Chemicals/CAS: cycloheximide, 642-81-9, 66-81-9; dactinomycin, 1402-38-6, 1402-58-0, 50-76-0; fibrinogen, 9001-32-5; interleukin 2, 85898-30-2; plasminogen activator inhibitor, 105844-41-5; plasminogen activator, 9039-53-6; plasminogen, 9001-91-6; Interleukin-1; Lipopolysaccharides; Recombinant Proteins; Tissue Plasminogen Activator, EC 3.4.21.68
Topics
alpha 2 antiplasmincycloheximidecytokinedactinomycinfibrinogeninterleukin 2lipopolysaccharideplasminogenplasminogen activatorplasminogen activator inhibitoranimal cellanimal experimentblood and hemopoietic systemdose responsedrug analysisdrug comparisondrug determinationdrug inhibitiondrug mechanismdrug monitoringdrug responseendothelium cellgreat blood vesselhuman cellin vitro studyintravenous drug administrationpharmacokineticsAnimalCells, CulturedEndotheliumFibrinolysisHumanInterleukin-1LipopolysaccharidesMaleMiceRatsRecombinant ProteinsSupport, Non-U.S. Gov'tTissue Plasminogen Activator
TNO Identifier
230085
ISSN
00221007
Source
Journal of Experimental Medicine, 163(5), pp. 1260-1266.
Pages
1260-1266
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