The effect of the apolipoprotein E phenotype on plasma lipids is not influenced by environmental variability: Results of a Dutch twin study

article






Knijff, P. de

Boomsma, D.I.

Wit, E. de

Kempen, H.J.M.

Gevers Leuven, J.A.

Frants, R.R.

Havekes, L.M.
We tested the influence of the apolipoprotein E (apoE) polymorphism on the intrapair differences in the levels of plasma cholesterol, plasma triglycerides, low density lipoprotein-cholesterol, apoB and apoE in monozygotic (MZ) twins, and estimated whether or not there was a interaction between the apoE polymorphism and environmental factors. In 65 MZ twin pairs, the intrapair differences in the measured lipoprotein parameters were similar in the different apoE phenotype classes. This indicates that the effect of the apoE polymorphism is not influenced by environmental variability between the MZ pair members and accordingly identifies the APOE gene as a 'level' gene.
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apolipoprotein bapolipoprotein elow density lipoprotein cholesteroladultcholesterol blood levelcontrolled studyenvironmental factorgene functionhuman celllipid blood levelmajor clinical studymonozygotic twinsnormal humanphenotypetriacylglycerol blood levelAdolescentAllelesAnalysis of VarianceApolipoproteins ECohort StudiesEnvironmentFemaleGene FrequencyHumanLipidsMaleMiddle AgeNetherlandsPhenotypeSupport, Non-U.S. Gov'tTwins, MonozygoticVariation (Genetics)
TNO Identifier
232091
Repository link
https://resolver.tno.nl/uuid:4c438ae9-a171-4842-9908-237c132c8997
ISSN
03406717
Source
Human Genetics, 91(3), pp. 268-272.
Pages
268-272
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