Endothelin-1 and -3 induce the release of tissue-type plasminogen activator and Von Willebrand factor from endothelial cells
article
Stimulation of the isolated perfused rat hindleg vascular bed with various concentrations of endothelin-1 or endothelin-3 resulted in the acute release of tissue-type plasminogen activator (t-PA) and of von Willebrand factor (vWF). The release of both endothelial of both endothelial cell products required the presence of extracellular calcium; the release of vWF by endothelin was instantly inhibited by disodium EDTA. The calcium antagonists nifedipine, diltiazem and verapamil partially inhibited endothelin-induced t-PA release, but had no effect on endothelin-induced vWF release.
Topics
TNO Identifier
231068
ISSN
00142999
Source
European Journal of Pharmacology, 187(1), pp. 105-112.
Pages
105-112
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