Coagulation and fibrinolysis markers and risk of dementia
article
We performed a cross-sectional case-control study among 277 subjects with dementia and 298 control subjects drawn from participants of the Rotterdam Study, a population-based cohort study among subjects aged 55 years or over, and from participants of the Rotterdam Stroke Databank, a hospital-based stroke registry, with the objective to evaluate the association of indicators of coagulability, fibrinogen, prothrombin fragments 1+2, thrombin-antithrombin complex (TAT), and indicators of fibrinolysis, plasmin-inhibitor complex, D-dimer and tissue-type plasminogen activator (t-PA) with dementia. Increased levels of TAT, D-dimer and t-PA activity were associated with an increased risk of dementia. Additional stratified analyses indicated that an increased TAT level was the primary factor related to dementia. The present study provides evidence that predominantly increased thrombin generation is associated with dementia. © 1999 S. Karger AG,.
Topics
AlzheimerAtherosclerosisD-dimerPlasminPlasmin inhibitorProthrombin fragments 1+2Thrombin-anti-thrombinVascular dementiaAgedAged, 80 and overAntifibrinolytic AgentsAntiplasminAntithrombin IIIBiological MarkersBlood CoagulationCase-Control StudiesCohort StudiesCross-Sectional StudiesDementiaDemographyFemaleFibrin Fibrinogen Degradation ProductsFibrinogenFibrinolysisHemostasisHumansMaleMiddle AgedNetherlandsPeptide FragmentsPeptide HydrolasesPlasminPopulationProtein PrecursorsProthrombinRisk FactorsTissue Plasminogen Activator
TNO Identifier
234777
ISSN
03010147
Source
Haemostasis, 28(3-4), pp. 216-222.
Pages
216-222
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