Effects of coffee and caffeine on tissue-type plasminogen activator and its fast-acting inhibitor, PAI-1, in vivo and in vitro

article



Kluft, C.

Kooistra, T.

Veenstra, J.

Schaafsma, G.
Results of studies on the long-term effects of coffee and caffeine consumption on plasma fibrinolytic variables are inconsistent. Possible direct effects of caffeine and caffeic acid on production of t-PA and PAI-1 by cultured human umbilicial cord endothelial cells (HUVEC) and HEP G2 were studied. High concentrations of caffeic acid slightly increased production of PAI-1 by HEP G2. At 'physiological' levels of caffeine, t-PA and PAI-1 production by HUVEC was approx. 20% reduced.
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caffeic acidcaffeineplasminogen activator inhibitor 1tissue plasminogen activatoradultcell cultureconference paperendothelium cellhumanhuman cellmalenormal humanMedicineGeneeskundePhysiologyFysiologieMedicineGeneeskundePhysiologyFysiologie
TNO Identifier
33009
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Source
Fibrinolysis, 4(suppl. 2), pp. 74-75.
Pages
74-75
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