Acute exogenous hyperinsulinaemia does not result in elevation of plasma plasminogen
activator inhibitor-1 (PAI-1) in humans
article
In vitro, insulin stimulates synthesis and release of PAI-1 by hepatocytes. To test whether insulin infusion results in elevation of PAI-1 levels in vivo, we studied PAI-1 levels in 9 obese, non-diabetic and in 10 obese, type II diabetic subjects during and after a sequential hyperinsulinaemic euglycaemic glucose clamp. Insulin levels up to ± 4500 mU/1 failed to overrule diurnal changes of PAI-1. PAI-1 levels 6 h after the start of a supraphysiologic at insulin dose were not different from control values at the same time of the day. These findings suggest that exogenous hyperinsulinaemia does not result in significant increases of PAI-1 in vivo.
TNO Identifier
244126
Source
Fibrinolysis, 4(suppl.2), pp. 93-94.
Pages
93-94
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