Ointments for the protection against organophosphate poisoning
article
Ointments for the protection against poisoning of the skin by highly toxic organophosphates or organo-phosphate insecticides were prepared and examined for their protective effect both on guinea-pig skin in vitro and on guinea-pigs in vivo. The results of these investigations were as follows:
1. The prophylactic application of the ointments yields 20fold reduction of the permeation rate of the toxic or-ganophosphate compared with unprotected skin.
2. The ointments on a polyethyleneglycol basis show their best protective effect if they contain both a base and an active substance.
3. Maximum possible protection can be achieved by applying a thick layer of ointment which should be mecha-nically removed (by wiping with a damp cellulose tissue) from the contamination site within 30 min.
1. The prophylactic application of the ointments yields 20fold reduction of the permeation rate of the toxic or-ganophosphate compared with unprotected skin.
2. The ointments on a polyethyleneglycol basis show their best protective effect if they contain both a base and an active substance.
3. Maximum possible protection can be achieved by applying a thick layer of ointment which should be mecha-nically removed (by wiping with a damp cellulose tissue) from the contamination site within 30 min.
TNO Identifier
763003
Source
Arzneimittel-Forschung / Drug Research, 32(6), pp. 630-633.
Place of publication
Rijswijk
Pages
630-633
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