Development of lactobacilli for mucosal immunization
bookPart
This chapter presents an overview of the development of lactic acid bacteria and Lactobacillus spp. as immune modulating entities. Many lactic acid bacteria (LAB) species are used for the manufacturing of fermented food products, varying from wine and yoghurt to cheese and dried sausages. LAB species can also be found as members of the natural microflora of living organisms. Lactobacilli are capable of persisting in the gastrointestinal tract for an extended period of time and show a significant immunomodulatory capability. Probiotic properties, some immunogenetic traits of lactobacilli, and the development of genetic tools are discussed in the chapter. In addition, the chapter presents a case study of lactobacilli as vaccine carriers. The goal for successful mucosal vaccination is to optimize priming of both systemic and mucosal immune compartments. Application of the Lactobacillus delivery systems and combination of these systems with existing or newly developed mucosal vaccine systems should lead to more knowledge of the mucosal immune system and to safe vaccines for both the human and animal population.
TNO Identifier
409836
Repository link
ISSN
18771823
Source title
Biology of Growing Animals
Pages
328-350
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