Mechanism of lung tumour colony reduction caused by coumarin anticoagulation
article
Anticoagulation of syngeneic C57BL mice with the coumarin derivative phenprocoumon at various time intervals before and after the intravenous injection of Lewis Lung carcinoma cells reduced the number of tumour colonies in the lung. The results suggested that this effect was independent of the alteration of the clotting mechanism of the host. Restoration of blood coagulability by administration of human factor IX complex did not abolish the antimetastatic effects of coumarin medication. Since diet induced vitamin K deficiency appeared to be equally effective in reducing lung tumour colonies, it was concluded that coumarins did not act directly on the tumour cell, but that the antimetastatic effect was mediated by the drug induced vitamin K deficiency. A hypothesis of the possible mode of action is presented.
TNO Identifier
354032
Source
European journal of cancer, 15, pp. 183-187.
Pages
183-187
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