Pigmented hyperplasia of epidermis following feeding of L dopa to elderly rats

article
Maat, B.
In view of clinical data supporting a causal relation between long-term L-dopa administration and recurrence of melanoma, long-term L-dopa administration to 35 aged rats was performed to investigate its effect on the incidence of malignant melanoma. Of the treated animals, 11% showed local pigmented epidermal hyperplasia, compared with 0.5% of the control animals, but the number of expected melanomas was not increased by L-dopa treatment. Chemicals/CAS: levodopa, 59-92-7; Levodopa; Melanins
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AgeAgedEpidermis hyperplasiaSkin pigmentationTheoretical studyAge FactorsAnimalHumanHyperplasiaLevodopaMaleMelaninsMelanomaNeoplasms, ExperimentalPigmentationPrecancerous ConditionsRatsRats, Inbred BNRecurrenceSkinSkin Neoplasms
TNO Identifier
228263
Repository link
https://resolver.tno.nl/uuid:1c00ce05-5593-4ac3-8315-1c755b05c25c
ISSN
00278874
Source
Journal of the National Cancer Institute, 58(5), pp. 1433-1436.
Pages
1433-1436
Files
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