Idiopathic paraproteinaemia. I. Studies in an animal model - the ageing C57BL/KaLwRij mouse

article



Radl, J.

Hollander, C.F.

Berg, P. van

Glopper, E. de
A search for a suitable animal model for studies on idiopathic paraproteinaemia showed that an age-dependent increase in the appearance of homogeneous immunoglobulins in serum was common to all of the seven mouse strains investigated to date. The highest frequency was found in C57Bl/KaLwRij mice. Further investigations in this strain demonstrated that, except for some quantitative differences, most of the features of human C57Bl mouse idiopathic paraproteinaemia were essentially the same. No clear-cut correlation was found between the idiopathic paraproteinaemia and, in the old C57Bl mice, a rather frequently occurring reticulum cell sarcoma B and amyloidosis. The mouse idiopathic paraproteinaemia can be ragarded as an analogue of the human idiopathic paraproteinaemia and therefore as a suitable model for further experimental studies.
Chemicals/CAS: Immunoglobulins
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animal modelbiological modelhyperimmunoglobulinemiain vitro studymouseparaproteinemiatheoretical studyAgingAmyloidosisAnimalComparative StudyDisease Models, AnimalFemaleHumanImmunoglobulinsLymphoma, Large-CellMaleMiceMice, Inbred C57BLMice, Inbred StrainsParaproteinemiasSex Factors
TNO Identifier
228463
Repository link
https://resolver.tno.nl/uuid:b7f36109-9c44-4854-870c-f6cca1b98fbe
ISSN
00099104
Source
Clinical and Experimental Immunology, 33(3), pp. 395-402.
Pages
395-402
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