Energy restriction, the basis for successful aging in man?
article
Restriction of energy intake (ER) without essential nutrient intake deficiency retards aging and extends life span in various animal species. Although several potential mechanisms have been put forward, the mechanism behind this phenomenon remains unknown. This review describes the effects of aging and energy restriction on three physiological systems (energy expenditure, free-radical activity and endocrine regulation) that are involved in the metabolic adaptation to ER and that seem to play an important role in the aging process. Since aging is a general biological phenomenon is seems likely that ER has the same beneficial effect on the aging process in man. This article summarizes the effects of ER and aging on these three physiological systems in both animals and man and attempts to explore the potential application of ER in man.
TNO Identifier
51015
ISSN
02715317
Source
Nutrition Research, 14(7), pp. 1113-1134.
Pages
1113-1134
Files
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