Intake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjects
article
Objective: High-sensitivity C-reactive protein (CRP), a marker of systemic inflammation, is a powerful predictor of cardiovascular risk. We hypothesised that n-3 fatty acids reduce underlying inflammatory processes and consequently CRP concentrations in healthy middle-aged subjects. Design: Placebo-controlled, double-blind study. Subjects: A total of 43 men and 41 postmenopausal women aged 50-70y. Before and after intervention, we measured serum CRP concentrations with an enzyme immunoassay. Interventions: Capsules with either 3.5 g/day fish oil (1.5 g/day n-3 fatty acids) or placebo for 12 weeks. Results: The median CRP change in the fish oil group did not significantly differ from that in the placebo group (0.01 vs -0.17 mg/l, P = 0.057). Conclusion: The currently available data -including ours- do not support that beneficial effects on CRP are involved in a mechanism explaining the protective effect on heart disease risk of n-3 fatty acids as present in fish. © 2004 Nature Publishing Group All rights reserved. Chemicals / CAS: C reactive protein, 9007-41-4; fish oil, 8016-13-5; Biological Markers; C-Reactive Protein, 9007-41-4; Dietary Fats, Unsaturated; Fatty Acids, Omega-3
Topics
Biomedical ResearchC-reactive proteinInflammationn-3 fatty acidsOmega-3 fatty acidsC reactive proteinfish oilomega 3 fatty acidplaceboadultcardiovascular riskclinical trialcontrolled clinical trialcontrolled studydata analysisdouble blind proceduredrug capsuleenzyme immunoassayheart protectionhypothesisinflammationpredictionprotein blood levelrandomized controlled trialstatistical analysisAgedAnimalsBiological MarkersC-Reactive ProteinDietary Fats, UnsaturatedDouble-Blind MethodFatty Acids, Omega-3FemaleFishesHumansImmunoenzyme TechniquesMaleMiddle AgedSeafood
TNO Identifier
238019
ISSN
09543007
Source
European Journal of Clinical Nutrition, 58(10), pp. 1440-1442.
Pages
1440-1442
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