Testing protective clothing, objective methods and pass/fail criteria for mustard agent penetration
conference paper
Human volunteer testing using mustard agent to evaluate the performance of protective clothing as was done in the past, is prohibited. Animal testing also has become severely limited. Therefore, testing is mostly done in the laboratory using detectors that are "passive
calibrated dosimeters acting like human skin". The pass fail criteria have been derived from the earlier human testing, penetration of 500 mg.min.m3 in a vapour/vapour test and 4 ug/cmz in a Liquid/vapour test for a sample combined with a thin PE film. Hidden in the sentences above are a series of problems:
- Is reliable animal friendly testing possible?
- What constitutes a passive calibrated dosimeter?
- How can we achieve that it acts like human skin?
- If a well-known toxicologist states that an exposure to
500 mg.min.m3 would cause serious skin burns, can we still rely on the pass/fail criteria?
In this paper it will be shown how we at TNO-PML have tried to answer these questions. The conclusion is that we have a "passive calibrated dosimeter acting like human skin" and reliable pass/fail criteria derived from old human volunteer testing.
calibrated dosimeters acting like human skin". The pass fail criteria have been derived from the earlier human testing, penetration of 500 mg.min.m3 in a vapour/vapour test and 4 ug/cmz in a Liquid/vapour test for a sample combined with a thin PE film. Hidden in the sentences above are a series of problems:
- Is reliable animal friendly testing possible?
- What constitutes a passive calibrated dosimeter?
- How can we achieve that it acts like human skin?
- If a well-known toxicologist states that an exposure to
500 mg.min.m3 would cause serious skin burns, can we still rely on the pass/fail criteria?
In this paper it will be shown how we at TNO-PML have tried to answer these questions. The conclusion is that we have a "passive calibrated dosimeter acting like human skin" and reliable pass/fail criteria derived from old human volunteer testing.
TNO Identifier
995569
Publisher
DSO National Laboratories
Source title
1st SISPAT Singapore - International Symposium on Protection against Toxic Chemicals, Singapore, 1-4 December 1998
Files
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