Effect of Brussels sprouts on oxidative DNA-damage in man
article
The effect of consumption of Brussels sprouts on the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) into human urine was investigated. Ten non-smoking volunteers (five males and five females) were randomly assigned to two groups. Five volunteers started on a diet of 300 g of glucosinolate-free vegetables whereas the other five consumed 300 g of Brussels sprouts per day. After 1 week dietary regimes were reversed. Levels of 8-oxodG in 24-h urine samples were measured by high-performance liquid chromatography. In four of five males a reduction in 8-oxodG was found, whereas in the fifth male the 8-oxodG excretion was high in the control period and was even much higher in the sprouts period. In females no effect of consumption of Brussels sprouts on excretion of 8-oxodG was found. Our previous and present findings support the results of epidemiologic studies that consumption of brassica vegetables may diminish cancer risk.
Topics
TNO Identifier
84926
DOI
https://dx.doi.org/10.1016/S0304-3835(97)04641-7
ISSN
03043835
Source
Cancer Letters, 114(1-2), pp. 127-130.
Pages
127-130
Files
To receive the publication files, please send an e-mail request to TNO Repository.