Monoclonal gammapathies - Are they all malignancies or premalignancies?
article
This short review of own work questions the wide spread clinical dogma that monoclonal gammapathies (MG) usually reflect a B cell malignancy or at least a pre-malignancy. Research on B-cell proliferative disorders in an animal model - the aging C57BUKaLwRij mouse - revealed that there are at least four major mechanisms in the development of MG. Many of the findings were confirmed in subsequent clinical studies and lead to a new classification of MG according to their biology and possible pathogenesis. Most of MG can be classified into one of the following 4 categories: 1. B- cell malignancies, 2. B-cell benign neoplasia, 3. MG due to an immunodeficiency with T/B cell imbalance, and 4. Antigen driven MG. The B- cell malignancies, i.e. MG of the first category, represent only ±1% of all MG detected by routine laboratories. However, there are no reliable tests available yet for the differential diagnosis among the 4 categories of MG in the clinical praxis. Copyright © 1997 Institute of Oncology in Sremska Kamenica, Yugoslavia
Topics
Animal modelsB cell proliferative disordersMonoclonal gammapathies-four categoriesMonoclonal gammapathies-pathogenesisanimal experimentB lymphocyte activationcell proliferationcontrolled studyimmunoglobulin productionmacroglobulinemiamonoclonal immunoglobulinemianonhumanparaproteinemiapathogenesisreview
TNO Identifier
233742
ISSN
03542351
Source
Archive of Oncology, 5(2), pp. 75-77.
Pages
75-77
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