Human glial cell culture models of inflammation in the central nervous system

article
Noort, J.M. van
Research into human central nervous system (CNS) disorders has traditionally focused on interconnecting neurons, thought to be the most important functional elements in the CNS. Consequently, animal models have developed as the central paradigm in CNS drug development. However, evidence is accumulating that suggests glial cells play a much more important role in health and disease in the CNS than has been previously acknowledged. Brain deveopment, neurotransmission, inflammatory and neuroprotective pathways and blood-brain barrier functions rely on glial cells. It is also the case that human glial cell cultures adequately mimic in vivo glial cell behaviour, providing a novel and valuable tool for CNS drug discovery and development. ©2006 Elsevier Ltd. All rights reserved. Chemicals / CAS: interleukin 8, 114308-91-7; macrophage inflammatory protein 1alpha, 155075-84-6; natalizumab, 189261-10-7; thymosin beta10, 87397-91-9
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Biomedical Researchbone morphogenetic protein 4calgranulinCD147 antigenCD40 antigencomplementary DNAcorticotropin releasing factor receptor 1endothelin 2gene productinterleukin 1 receptor blocking agentinterleukin 17interleukin 1betainterleukin 8macrophage inflammatory protein 1alphamonocyte chemotactic protein 1natalizumabnerve growth factor receptorneuromodulinribonuclease angiogenin inhibitorthymosin beta10tumor necrosis factor alphaunclassified drugvasculotropin receptor 1angiogenesisastrocytecell heterogeneityDNA microarrayencephalitisfunctional genomicsgene expression profilinggenetic variabilityglia cellJC virusmicrogliamolecular mimicrymultiple sclerosisnerve cell cultureneuroprotectionreviewT lymphocyte activationupregulationvirus infectionAnimalsAstrocytesCells, CulturedCentral Nervous System DiseasesDrug DesignHumansInflammationMicroglia
TNO Identifier
239066
Repository link
https://resolver.tno.nl/uuid:c07c80be-2af0-4907-9b2c-2c2641f5f76d
ISSN
13596446
Source
Drug Discovery Today, 11(1-2), pp. 74-80.
Pages
74-80
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