TNO Ldlr-/-.Leiden Mash mouse model
other
Metabolic dysfunction-associated steatohepatitis (MASH; formerly known as NASH) is one of the most prevalent chronic liver diseases and is closely associated with obesity, insulin resistance and dyslipidemia. These important features therefore need to be reflected in a preclinical model. Based on 25 years of research on translational metabolic disease models, TNO has developed the Ldlr-/-.Leiden mouse that accurately mimics the etiology and pathology of MASH and fibrosis in humans. By using a high-fat diet, with a macronutrient composition comparable to that of human diets (e.g., without added cholesterol), Ldlr-/-.Leiden mice develop obesity, insulin resistance, adipose tissue inflammation, increased gut permeability with altered microbiota composition, and MASH with bridging fibrosis (F3).
TNO Identifier
993172
Publisher
TNO
Collation
8 p.
Place of publication
Leiden