Selective on-line precolumn sample handling and trace enrichment in liquid chromatography
doctoral thesis
Many sample preparation procedures include sample dissolution followed by liquid-liquid extraction. Traditional liquid-liquid extractions are performed in separatory funnels. Frequently, they are tedious, time-consuming and costly. These methods not only require several sample handling steps, but may present problems such as emulsifications, the evaporation of large solvent volumes, the disposal of toxic and inflammable solvents, impure and wet extracts, non-quantitative and ineproducible extraction yields. A highly promising approach is to enrich trace compounds of interest on suitable sorbents, in order to isolate and preconcentrate them prior to their separation and detection by means of a suitable chromatographic technique. Nowadays, this approach has become a popular topic in many reviews.
TNO Identifier
359510
Collation
154 p.