Influence of some organic and inorganic ions on fibrinolysis in vitro
article
When measuring the activity of purified fibrinolytic enzymes, it is important to know whether ions present in the medium (such as calcium) and buffer constituents might contribute to the response measured. The influence of such compounds has only been incidentally studied. The present study was undertaken to more systematically measure the influence of ionic compounds frequently used in the test medium on fibrinolysis in vitro. The use of purified fibrin enabled to distinguish among three types of interaction of a particular compound with the fibrinolytic system. The compounds studied for their influence upon fibrinolysis were incorporated into the fibrin substrate.
Chemicals/CAS: ammonium chloride, 12125-02-9; borate sodium, 12447-40-4, 1303-96-4, 1330-43-4, 1333-73-9, 32446-62-1, 61028-24-8; calcium, 7440-70-2; citrate sodium, 18996-35-5, 994-36-5; citric acid, 126-44-3, 5949-29-1, 77-92-9, 8002-14-0; cysteine, 4371-52-2, 52-89-1, 52-90-4; edetic acid, 150-43-6, 60-00-4; fibrinogen, 9001-32-5; flufenamic acid, 1977-00-0, 530-78-9; glycine ethyl ester, 459-73-4; magnesium chloride, 7786-30-3, 7791-18-6; plasmin, 9001-90-5, 9004-09-5; plasminogen activator, 9039-53-6; plasminogen, 9001-91-6; strontium chloride, 10476-85-4; thrombin, 9002-04-4; trometamol, 1185-53-1, 77-86-1; urea, 57-13-6; urokinase, 139639-24-0; Calcium, 7440-70-2; Cations, Divalent; Fibrinolytic Agents; Ions; Magnesium, 7439-95-4; Potassium, 7440-09-7; Sodium, 7440-23-5; Strontium, 7440-24-6
Chemicals/CAS: ammonium chloride, 12125-02-9; borate sodium, 12447-40-4, 1303-96-4, 1330-43-4, 1333-73-9, 32446-62-1, 61028-24-8; calcium, 7440-70-2; citrate sodium, 18996-35-5, 994-36-5; citric acid, 126-44-3, 5949-29-1, 77-92-9, 8002-14-0; cysteine, 4371-52-2, 52-89-1, 52-90-4; edetic acid, 150-43-6, 60-00-4; fibrinogen, 9001-32-5; flufenamic acid, 1977-00-0, 530-78-9; glycine ethyl ester, 459-73-4; magnesium chloride, 7786-30-3, 7791-18-6; plasmin, 9001-90-5, 9004-09-5; plasminogen activator, 9039-53-6; plasminogen, 9001-91-6; strontium chloride, 10476-85-4; thrombin, 9002-04-4; trometamol, 1185-53-1, 77-86-1; urea, 57-13-6; urokinase, 139639-24-0; Calcium, 7440-70-2; Cations, Divalent; Fibrinolytic Agents; Ions; Magnesium, 7439-95-4; Potassium, 7440-09-7; Sodium, 7440-23-5; Strontium, 7440-24-6
Topics
ammonium chlorideborate sodiumcalciumcitrate sodiumcitric acidcysteineedetic acidfibrinogenfibrinolytic agentflufenamic acidglycine ethyl estermagnesium chlorideplasminplasminogenplasminogen activatorstrontium chloridethrombintrometamolureaurokinase3,5 dibromosalicylic aciddrug analysisdrug mechanismdrug synthesisfibrinolysishumanin vitro studymetaboliteoxalate potassiumtheoretical studythrombosistissue activatorAnimalBlood Coagulation TestsCalciumCations, DivalentCattleChemistry, OrganicFibrinolysisFibrinolytic AgentsIn VitroIonsMagnesiumPotassiumSodiumStrontium
TNO Identifier
228061
ISSN
03234347
Source
Folia Haematologica, 103(3), pp. 389-398.
Pages
389-398
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