Les divers aspects du syndrome secondaire compliquant les transfusions allogéniques de moelle osseuse ou de leucocytes chez des sujets atteints d'hémopathies malignes
article
Fourteen cases of secondary syndrome in Man, complicating transfusions of allogeneic bone marrow after total irradiation at lethal dose, or transfusions of leukocytes, are analysed. The clinical signs (general, digestive, hepatic, cutaneous, lymphoid, various visceral), the haematological signs (anaemia, lymphocytopenia, eosinophilia), the histological lesions (hyperbasophilic cell proliferation, lymphoid aplasia, necroses), the biochemical disorders (anomalies of the serum immunoglobulin levels and of various serum enzymes) are described and compared with those observed in several animal species. Data collected in Man contribute to prove that the essential physiopathologic process is to be found in the reaction of the graft to the host, as is the case in the animal. This reaction, while unfavourable since it is the cause of the secondary syndrome, may nevertheless be used as immunotherapy in leukaemia: the results obtained in this respect in three patients are encouraging; one of them, a total haematopoietic chimera (myeloid and lymphoid) showed a normal haematological picture after 20 months. Apparently complete remissions were obtained after leukocyte transfusions in 3 out of 6 patients with acute lymphoblastic leukaemia. It is suggested that this antileukaemic effect is also due to the reaction of the graft to the host. The value of the means used to control the secondary syndrome is analysed: it seems that the use of multiple donors and of amethopterin after cell transfusions may be really effective. © 1965.
Topics
TNO Identifier
226893
ISSN
00142964
Source
European Journal of Cancer, 1(2), pp. 75-88.
Pages
75-88
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