Synergism between ethanol and carbon tetrachloride in the generation of liver fibrosis
article
In this study, alcohol-induced histological lesions in a short-term experimental rat model wer compared with those characteristic of human alcoholic liver disease. In the rat model used, pretreatment with carbon tetrachloride (CCl4) for 6 weeks was employed posibly to sensitize the liver for the effects of alcohol and shorten the time of induction of alcoholic liver disease. After 6 weeks of CCl4 treatment, subsequent maintenance on drinking water containing up to 10 per cent alcohol for 7 weeks potentiated liver fibroplasia as compared wityh non-alcohol-treated rats. However, steatosis and alcoholic hepatitis, as histological evidence for alcoholic liver disease as seen in humans, were not observed. In non-CCl4-pretreated control animals, alcohol administration had no effect on liver histology. It can be concluded that in the model used, CCl4 pretreatment sensitizes the liver to increase colllagen deposition following alcohol administration, but not to steatosis of alcoholic hepatitis as seen in human alcoholic liver disease. In this experimental set-up, direct metabolic interaction of CCl4 with alcohol as a cause of the increased fibroplasia can be excluded.
Chemicals/CAS: alcohol, 64-17-5; carbon tetrachloride, 56-23-5; collagen, 9007-34-5; Carbon Tetrachloride, 56-23-5; Ethanol, 64-17-5
Chemicals/CAS: alcohol, 64-17-5; carbon tetrachloride, 56-23-5; collagen, 9007-34-5; Carbon Tetrachloride, 56-23-5; Ethanol, 64-17-5
Topics
TNO Identifier
230633
ISSN
00223417
Source
Journal of Pathology, 156(1), pp. 15-21.
Pages
15-21
Files
To receive the publication files, please send an e-mail request to TNO Repository.