Leukocyte antigens of rhesus monkeys (RhL-A) and chimpanzees (ChL-A) : similarities with the human HL-A system
article
The current state of tissue typing in Rhesus monkeys and chimpanzees is described. Data are presented, suggesting that the antigens of the Rhesus monkey's major histocompatibility system (RhL-A) may well be controlled by two closely linked series of allelic genes, as is also the case for the human HL-A system. Furthermore, methods for the production of typing reagents of high specificity by planned inter-sib immunizations are described. For chimpanzees, advantages in the use of the complement-fixation test are emphasized. Specificities previously established with a microcytotoxicity method seem to be better defined if the complement-fixation test is used. The currently known specificities of the chimpanzee's major histocompatibility system (ChL-A) were once again compared with the human HL-A system. Several new similarities between both systems are reported. These similarities confirm the phylogenetic closeness between chimpanzee and man and reflect on the evolution of the human HL-A system.
TNO Identifier
355962
Source
Tissue Antigens, 1, pp. 229-238.
Pages
229-238
Files
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