No guts no glory: metabolic phenotyping and microbiome lessons learned
other
The importance of fibre intake for our general health, and not only for our gut microbiota, is appreciated more and more. However, average consumption is far below the recommended amounts. In the Netherlands women consume on average 18 grams of fibre per day while the recommendation is 30 grams, and men consume about 22 grams of the recommended 40 grams per day. Fibre consumption affects our microbiome composition which also affects microbiome function.
Therefore, health can be influenced by changing gut microbiome composition. A randomized placebo-controlled crossover clinical trial was performed called No Guts No Glory. In this study we evaluated the effect of 12 weeks of daily nutritional fibre consumption (13g in the form of a dietary supplement) on gut microbiome composition in relation to post-prandial responses of plasma biomarkers reflecting metabolism. We investigated if there is a relation between microbiome modulation and metabolic flexibility. Furthermore, we investigated the possibility to compare individual in vitro fermentation effects of the fibre mixture to the effects of 12 week fibre consumption in a clinical setting for future pre-screening possibilities.
Therefore, health can be influenced by changing gut microbiome composition. A randomized placebo-controlled crossover clinical trial was performed called No Guts No Glory. In this study we evaluated the effect of 12 weeks of daily nutritional fibre consumption (13g in the form of a dietary supplement) on gut microbiome composition in relation to post-prandial responses of plasma biomarkers reflecting metabolism. We investigated if there is a relation between microbiome modulation and metabolic flexibility. Furthermore, we investigated the possibility to compare individual in vitro fermentation effects of the fibre mixture to the effects of 12 week fibre consumption in a clinical setting for future pre-screening possibilities.
TNO Identifier
989876
Publisher
TNO
Source title
Optimising Food and Fibre Composition for Enhancing Microbial and General Health TNO Symposium, 20 september 2023, Naturalis Leiden
Collation
11 p.
Place of publication
Leiden
Files
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