Oncogenicity of murine mammary tumor virus produced in tissue culture : brief communication

article


Arthur, L.O.

Fine, D.L.

Bentvelzen, P.A.J.
Murine mammary tumour virus (MuMTV), produced from a glucocorticoid-stimulated C3H mouse mammary adenocarcinoma cell line, was free of murine leukemia virus and oncogenic for weanling BALB/c mice. Adenocarcinomas were induced by MuMTV as early as 136 days post inoculation and with as low as 5 × 10^3 virus particles/mouse. Tumor incidence did not correlate directly with virus dose; rather, it was low at higher MuMTV concentrations (1.2 × 10^8 particles/mouse), reached an optimum at 1.3 × 10^5 particles/mouse, and decreased with virus dilution.
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AdenocarcinomaGlucocorticoidsCell lineMurine leukemia virusMammary tumor virusMouseMice, inbred balb cMice, inbred c3hTissue cultureVaccinationVirionMiceNeoplasmsVirusesAdenocarcinoma of breastDilution techniqueDilute (action)
TNO Identifier
354997
Repository link
https://resolver.tno.nl/uuid:e0e70e79-be5a-495a-abbf-5970c4878c7e
Source
Journal of the National Cancer Institute, 60(2), pp. 461-464.
Pages
461-464
Files
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