Genetical aspects of endogenous mammary tumor virus expression in mice reinvestigated
article
Milk samples of progeny mice from crosses between mouse strains which differ in the degree of release of endogenous murine mammary tumour virus (MuMTV) were tested for the presence of MuMTV antigens by means of the Sepharose bead immunofluorescence assay. The results indicated that as compared to the nonexpressor strain BALB/c, a single dominant gene controls the release of a MuMTV in the C3Hf strain. However, the low-cancer strain C57BL carries a dominant, epistatic gene which can inhibit virus release in the hybrid with C3Hf to a large extent. The GRS strain harbours a dominant gene which, in F1 hybrids of all mouse strains tested, causes the release of large quantities of a virus (MuMTV-P) which causes tumours at an early age. Other genetic factors control the release of a lesser oncogenic virus in the GRS strain. The animals tested for MuMTV antigens were subsequently forcibly bred for mammary carcinoma production. There is a good correlation between virus release at a young age and tumour development at a late age, but a substantial number of mice which were virus-negative nevertheless developed a mammary tumour.
TNO Identifier
353621
Source
Breast cancer: new concepts in etiology and control, 14(10), pp. 1137-1147.
Pages
1137-1147
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