Interaction between viral and genetic factors in murine mammary cancer
article
This chapter focuses on the genetics of susceptibility to mammary tumorigenesis under the influence of (1) exogenous virus infections and (2) the genetic control of the release of endogenous viruses and subsequent tumorigenesis. Essentially, it describes the transmission of mammary tumor virus (MTV), genetics of susceptibility to exogenous MTV, and endogenous viruses. It also presents some instances in which mammary tumors occur without clear demonstration of virus expression. MTV has a relatively wide organ distribution; however, the mammary gland is the only tissue that can be transformed by MTV. An important aspect of endogenous mammary tumor viruses in mice is their oncogenicity for the natural host. Endogenous mammary tumor viruses are considered good tools for understanding neoplastic transformation. In contrast to the somatic provirus, the germinal provirus is present in all cells of the organism and is transmitted via the germ cells to the offspring. The somatic provirus can be present only in those cell species that have a receptor for the exogenous virus.
TNO Identifier
353229
Source
Advances in cancer research, 26, pp. 143-195.
Pages
143-195
Files
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