Neue Gesichtspunkte der Melanompathogenese : Eigenschaften metastasierender und nicht-metastasierender humaner Melanomzellen
bookPart
In the pathogenesis qf human tumors the capacity of tumor cells to form metastases is one of the most crucial events. Ther^ore, the unravelling of molecular mechanisms involved in the process of metastasis is very important. Next to a great number of other factors, extracellular proteases and adhesion molecules of the integrin superfamily deserve, due tot their strategic role, our special attention. In this contribution we describe the phenotypical and functional characterization of a set of human melanoma cell lines. Especially the expression of components of the plasminogen activation system and members of the integrin superfamily has been studied and compared with the expression in fresh human melanocytic lesions. Our data support the importance of these molecules in the pathogenesis of melanoma metastasis formation. Furthermore, our results open new perspectives for clinical application, e.g. diagnosis and prognosis.
Topics
TNO Identifier
289305
Publisher
Biermann Verlag
Source title
Jahrbuch der Dermatologie
Pages
101-112
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