The postoperative fibrinolytic shutdown : a rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma

article







Kluft, C.

Verheijen, J.H.

Jie, A.F.H.

Rijken, D.C.

Preston, F.E.

Sue-Ling, H.M.

Jespersen, J.

Aasen, A.O.
The plasma activity level of the recently discovered fast-acting inhibitor of tissue-type plasminogen activator (t-PA) was found to be temporarily increased after surgery, myocardial infarction and severe trauma. Detailed analysis of the postoperative period revealed simultaneously increased t-PA antigen and inhibition and decreased t-PA activity only on the first postoperative day. These changes were more rapid than those in fibrinogen and C-reactive protein. It is concluded that t-PA inhibition shows the most rapidly changing pattern observed so far in response to trauma. The postoperative fibrinolytic shutdown in blood fibrinolytic activity can be ascribed to a primary increase in t-PA inhibitor levels. Chemicals/CAS: C reactive protein, 9007-41-4; fibrinogen, 9001-32-5; plasminogen activator, 9039-53-6; tissue plasminogen activator, 105913-11-9; Antigens; Tissue Plasminogen Activator, EC 3.4.21.68
Topics
















C reactive proteinFibrinogenPlasminogen activatorClinical articleDiagnosisHeartHeart infarctionHumanInjurySurgeryAntigensFibrinolysisFracturesHumanPostoperative PeriodSupport, Non-U.S. Gov'tTissue Plasminogen Activator
TNO Identifier
288797
Repository link
https://resolver.tno.nl/uuid:f2e9bd95-4e0f-4c5e-9375-13fe3d17559f
Source
Scandinavian journal of clinical and laboratory investigation, 45, pp. 605-610.
Pages
605-610
Files
To receive the publication files, please send an e-mail request to TNO Repository.