C1 inhibitor : The main inhibitor of human plasma kallikrein
conference paper
The relative importance of two plasma inhibitors C1 inhibitor and α_2-macroglobulin in the inhibition of plasma kallikrein was studied using the synthetic substrate PPAN. The inhibition of plasma kallikrein by purified inhibitors as well as by normal plasma and inhibitor-depleted plasma was determined. The sensitivity of purified kallikrein, kallikrein complex and kallikrein endogenously generated in plasmas to the inhibitors was similar. There was a marked difference between the two inhibitors in the kallikrein inhibition. Initially, C1 inhibitor very rapidly inactivated the kallikrein activities, but the process proceeded only slowly towards completion. This was in contrast to α_2-macroglobul in which only caused a very slow decrease in the kallikrein activities. The absence of C1 inhibitor in plasmas led to a change in the kallikrein inhibition pattern i.e. a decrease in the inhibition of the amidolytic activity, indicating the importance of C1 inhibitor for rapid kallikrein inhibition in plasma.
TNO Identifier
288568
Source title
Proceedings of the Satellite Symposium of the 7th International congress of pharmacology, Paris, 22 July 1978
Pages
93-101
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