Resting levels of blood fibrinolysis in hyperlipoproteinemia
article
To correlate resting levels of blood fibrinolysis with different types of hyperlipidemia, the concentrations of fibrinogen and plasminogen and the euglobulin activity (precipitated at pH 5.9 and assayed on fibrin plates prepared with bovine, plasminogen-rich fibrinogen) were determined in fasting plasma samples from a group of normal controls ( 13 subj) and from 44 patients with hyperlipoproteinemia (type I: l; type II: 12; type III: 6; type IV (untreated): 13; type IV (treated): 5; type V: 7). Group levels of fibrinogen and plasminogen were normal or near normal, with a few cases of individually low plasminogen values in some type II and type IV patients. Mean fibrinolytic activity was normal in all groups, despite abnormally wide variations within patient groups. Screening of inhibition of plasmin, urokinase, and tissue plasminogen activator (porcine) demonstrated several instances of increased inhibition of tissue plasminogen activator in the patient groups and the control group. A study of individual data failed to reveal a correlation between the data obtained and lipid levels or patterns of plasma lipoproteins, precluding any simple relationship between hyperlipoproteinemia and blood fibrinolysis. Copyright © 1974 American Physiological Society. All rights reserved.
TNO Identifier
288033
Source
Journal of applied physiology, 36(4), pp. 430-433.
Pages
430-433
Files
To receive the publication files, please send an e-mail request to TNO Repository.