Clinical implications of vitamin B12 as redox-active cofactor
article
Vitamin B12 is a redox-active compound containing a cobalt atom that cycles between oxidation states. Superoxide scavenging induces its oxidation, disabling activation of the enzymes methionine synthase and methylmalonyl-CoA mutase, disrupting gene expression and energy production. High-dosed vitamin B12 may be clinically used to reduce oxidative stress and preserve cofactor functions. © 2021 Elsevier Ltd
TNO Identifier
958176
Source
Trends in Molecular Medicine, 27(10), pp. 931-934.
Pages
931-934
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