Pharmacokinetic application of normothermic perfused ex vivo porcine livers: poster
other
Current models to predict biliary excretion often fail due to species differences (rodent/dog) or due to differences in transporter expression in in vitro assays (e.g. sandwich cultured hepatocytes). Especially when drugs are subjective to enterohepatic circulation (EHC), this results difficulties to predict plasma profiles after oral and iv administration. Moreover, in case a compound is subjective to EHC, it is more prone to cause any drug-drug interaction and/or drug induced liver injury.
TNO Identifier
871813
Publisher
TNO ; LUMC
Source title
12th International Society for the Study of Xenobotics (ISSX), 28–31 July 2019, Portland USA