Enzymology and regulation of the atropine metabolism in Pseudomonas putida
doctoral thesis
The breakdown of a chemical compound in living organisms is accomplished usually by a sequence of enzyme catalyzed reactions. As a result, such a compound is broken down by a fixed pattern, the metabolic pathway. In most cases, the cells in an organism are able to control the synthesis and activity of the enzymes involved. In this way, the cells are able to fine tune the capacity of a metabolic pathway to the actual demand. This PhD thesis research deals with the metabolism of the alkaloid atropine, in the bacterium Pseudomonas putida. It includes a study of the metabolic pathway of atropine in the bacterium and the enzymes involved. In addition, a special mechanism has been elucidated by which the regulation of this metabolic activity is accomplished. This thesis was written in the Dutch Language in 1969. Only in 2019 the thesis was translated (by the author) in English as an exact copy, nearly page by page, of the 1969 version (no update). The English translation is only meant to disseminate the scientific data, described in the Dutch version. It does not intend to add any new data. In case of differences in the interpretation of the intellectual property, only the Dutch version counts.
TNO Identifier
867412
Publisher
Rijksuniversiteit Leiden
Collation
164 p.
Place of publication
Leiden