Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy

article










Graepel, R.

Braak, B. ter

Escher, S.E.

Fisher, C.

Gardner, I.

Kamp, H.

Kroese, D.

Leist, M.

Moné, M.J.

Pastor, M.

Water, B. van de
The EU-ToxRisk research project is an interdisciplinary research project that aims to advance the paradigm shift in toxicology towards new approach methodology (NAM)–based approaches for risk assessment. In this European research project, experts in the fields of in vitro and in silico techniques and risk assessment from academia, industry and regulatory agencies work together. Using a series of custom-designed case studies, the EU-ToxRisk battery of NAMs is being evaluated to learn how to carry out safety assessment using NAMs. This review article provides an overview of the project, its aims and approach and the methodologies that are being used. © 2019
Topics



Hazard assessmentMechanism-based testingin vitroin silicoRepeated dose toxicity (RDT)Developmental and reproductive toxicity (DART)
TNO Identifier
866943
Repository link
https://resolver.tno.nl/uuid:65952f08-61e3-401b-83f4-cefa11c4125b
ISSN
24682020
Source
Current Opinion in Toxicology, 15, pp. 33-39.
Pages
33-39
Files
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