Factors associated with pentosidine accumulation in the human vitreous
article
Purpose: To explore factors associated with pentosidine accumulation in the human vitreous. Methods: Vitreous samples were obtained during trans pars plana vitrectomy for macular hole or rhegmatogenous retinal detachment. Patient characteristics included age, gender, and diabetes mellitus. Ocular characteristics included pseudophakia, posterior vitreous detachment, and presence of intraocular fibrosis (epiretinal membrane, proliferative vitreoretinopathy, or both). Pentosidine concentration as a measure of accumulation of advanced glycation end products was determined by high performance liquid chromatography. Results: Pentosidine concentrations were measured in 222 vitrectomy samples (118 female and 104 male patients [median age 66 years], treated for macular hole [n = 105] or rhegmatogenous retinal detachment [n = 117]). Pentosidine was found to accumulate significantly with age (P < 0.001). After correction for age, a multivariable linear regression model revealed significantly higher pentosidine values in eyes with intraocular fibrosis (P = 0.001), in phakic as compared with pseudophakic eyes (P = 0.02), and in the absence of a complete posterior vitreous detachment (P = 0.018). The authors found no association with diabetes mellitus or gender. Conclusion: This study confirmed an age-related pentosidine accumulation in the vitreous and found new factors relating to pentosidine levels. Findings support the hypothesis of enzyme-induced vitreous liquefaction and the hypothesis of pentosidine as a pro-fibrotic factor. © by Opthalmic Communications Society, Inc. Chemicals / CAS pentosidine, 124505-87-9; arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; lysine, 56-87-1, 6899-06-5, 70-54-2; Arginine; Lysine; pentosidine.
Topics
Epiretinal membranePentosidinePosterior vitreous detachmentProliferative vitreoretinopathyVitreousadvanced glycation end productconcentration (parameters)diabetes mellitusgenderhigh performance liquid chromatographykeratopathymajor clinical studyocular fibrosispars plana vitrectomyretina detachmentretina macula holetrans pars plana vitrectomyvitreoretinopathyanalogs and derivativesmetabolismmiddle agedregression analysissex differencevery elderlyAdultAgedAged, 80 and overAgingArginineFemaleHumansLysineMaleMiddle AgedPseudophakiaRegression AnalysisSex FactorsVitreous BodyVitreous DetachmentYoung Adult
TNO Identifier
954928
ISSN
0275004X
Source
Retina, 37(4), pp. 770-777.
Pages
770-777
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