Disturbance of oxidative phosphorylation by an antibioticum produced by pseudomonas cocovenenans
article
The effect of a very toxic agent with antibiotic properties (bongkrekic acid), produced by Pseudomonas cocovenenans, on the oxidation of citric acid cycle intermediates catalyzed by heart muscle tissue has been investigated. It was found that the oxidation of pyruvate, α-ketoglutarate and malate was inhibited, whereas oxidation of succinate and β-hydroxybutyrate was stimulated. The phosphorylation, coupled with these oxidations proved to be even more sensitive to bongkrekic acid. The concentration required to produce these effects on isolated mitochondria is very low; in most cases 10<sup>-6</sup> M is very effective. © 1960.
TNO Identifier
280825
ISSN
00062952
Source
Biochemical Pharmacology, 3(2), pp. 122-135.
Pages
122-135
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