Combined gas chromatography-mass spectrometry: A powerful tool in analytical chemistry
article
A brief historical survey is given, together with a review of the main requirements for obtaining an optimal GC-MS system. Special attention is paid to the many different coupling techniques that have been developed during the last 15 years. The necessity for computerization and the various operational techniques applied in GC-MS are discussed and illustrated. Examples derived from the daily practice of an analytical laboratory are used to illustrate the different methods applied in GC-MS analyses of complex mixtures, such as low- and high-resolution multi-component GC-MS analyses, computer-aided mass fragmentography, spectrum subtraction procedures, interference problems occurring in multiple and single ion detection (low and medium resolution) and chemical ionization. © 1979.
TNO Identifier
280754
ISSN
00219673
Source
Journal of Chromatography A, 165(3), pp. 207-233.
Pages
207-233
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