Major histocompatibility complex class I-associated vaccine protection from simian immunodeficiency virus-infected peripheral blood cells
article
To evaluate the effectiveness of vaccine protection from infected cells from another individual of the same species, vaccinated rhesus macaques (Macaca mulatta) were challenged with peripheral blood mononuclear cells from another animal diagnosed with acquired immune deficiency syndrome (AIDS). Half of the simian immunodeficiency virus (SIV)-vaccinated animals challenged were protected, whereas unprotected vaccinates progressed as rapidly to AIDS. Protection was unrelated to either total antibody titers to human cells, used in the production of the vaccine, to HLA antibodies or to virus neutralizing activity. However, analysis of the serotype of each animal revealed that all animals protected against cell-associated virus challenge were those which were SIV vaccinated and which shared a particular major histocompatibility complex (MHC) class I allele (Mamu-A26) with the donor of the infected cells. Cytotoxic T lymphocytes (CTL) specific for SIV envelope protein were detected in three of four protected animals vs. one of four unprotected animals, suggesting a possible role of MHC class I-restricted CTL in protection from infected blood cells. These findings have possible implications for the design of vaccines for intracellular pathogens such as human immunodeficiency virus (HIV).
Topics
Glycoprotein gp 120Major histocompatibility antigen class 1Measles vaccineNeutralizing antibodyVirus vaccineAcquired immune deficiency syndromeAnimal cellAnimal experimentAnimal modelAntibody titerControlled studyCytotoxic t lymphocyteMajor histocompatibility complex restrictionMononuclear cellNonhumanPolymerase chain reactionProvocation testRhesus monkeySerotypeSimian immunodeficiency virusVaccinationVirus neutralizationAmino Acid SequenceAnimalsHistocompatibility Antigens Class IHumanMacaca mulattaMolecular Sequence DataSequence Homology, Amino AcidSimian Acquired Immunodeficiency SyndromeSIVViral VaccinesHistocompatibility Antigens Class IViral Vaccines
TNO Identifier
280582
ISSN
0022-1007
Source
Journal of Experimental Medicine, 180(2), pp. 769-774.
Pages
769-774