Relevance of bioaccumulating substances in the TTC concept
article
Recently, the European Food Safety Authority (EFSA) stated that the Threshold of Toxicological Concern
(TTC) thresholds should not be used for substances that are known or predicted to accumulate. Bioaccumulation
of substances is usually considered unfavourable but so far a relation with toxicity at low
dose exposure is insufficiently investigated to draw conclusions on the relevance of bioaccumulation at
low dose exposure. In this manuscript it is investigated which physical chemical properties are related to
bioaccumulation in order to predict accumulating properties of a substance, and is evaluated if the
toxicity of known bioaccumulating substances is higher than for non-accumulating substances. Based on
the evaluation it is concluded that the current TTC thresholds are derived with a dataset in which bioaccumulating
substances are present, whereas the toxicity of the bioaccumulating substances is already
taken into account in the TTC thresholds. The authors demonstrated that there is no need to exclude
potential bioaccumulating substances from the TTC concept.
(TTC) thresholds should not be used for substances that are known or predicted to accumulate. Bioaccumulation
of substances is usually considered unfavourable but so far a relation with toxicity at low
dose exposure is insufficiently investigated to draw conclusions on the relevance of bioaccumulation at
low dose exposure. In this manuscript it is investigated which physical chemical properties are related to
bioaccumulation in order to predict accumulating properties of a substance, and is evaluated if the
toxicity of known bioaccumulating substances is higher than for non-accumulating substances. Based on
the evaluation it is concluded that the current TTC thresholds are derived with a dataset in which bioaccumulating
substances are present, whereas the toxicity of the bioaccumulating substances is already
taken into account in the TTC thresholds. The authors demonstrated that there is no need to exclude
potential bioaccumulating substances from the TTC concept.
TNO Identifier
533307
Source
Regulatory Toxicology and Pharmacology, 77, pp. 42-48.
Pages
42-48
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